QUALITIDE

What is Tetrapeptide-30?

Tetrapeptide-30 (INCI: PKEK – Pro-Lys-Glu-Lys) is a synthetic skin-active peptide derived from the KEK motif found in the natural antimicrobial polypeptide cathelicidin. This multifunctional tetrapeptide is designed to reduce hyperpigmentation, boost skin firmness, and promote cell renewal — making it an ideal ingredient for both anti-aging and skin-brightening formulations.

Key Benefits of Tetrapeptide-30

Hyperpigmentation Control

Unlike standard tyrosinase inhibitors, Tetrapeptide-30 targets the upstream triggers of melanogenesis, specifically inflammatory cytokines (IL-6 and IL-8) and α-MSH production. This helps fade UV- or inflammation-induced dark spots, melasma, and post-inflammatory hyperpigmentation (PIH).

Tetrapeptide-30 Skin Cell Renewal

By soothing inflammation and supporting a healthy epidermal environment, Tetrapeptide-30 promotes skin cell turnover, improving tone, texture, and clarity over time.

Skin Brightening Without Irritation

Reduces hyperchromatic age spots and evens out skin tone without triggering sensitivity. Excellent for all skin types, including sensitive, Asian, and melanated skin tones.

Tetrapeptide-30 for Skin Firmness

While reducing pigmentation, Tetrapeptide-30 also improves skin firmness and elasticity, making it a multifunctional option for anti-aging skincare.

Tetrapeptide-30 Anti-Aging Peptide

Combines brightening and anti-inflammatory properties to reduce both visible signs of aging (like fine lines and dullness) and underlying skin stress that contributes to aging.

Applications

Tetrapeptide-30 is ideal for inclusion in:

• Brightening serums and creams
• Post-acne or post-laser PIH treatments
• Melasma and discoloration control formulas
• Anti-aging creams for dull, uneven skin
• Barrier-repair products for sensitive skin

Technical & Raw Material Info

• Synonyms: TEGO® Pep 4-Even, PKEK peptide
• Peptide Sequence: Pro-Lys-Glu-Lys
• Functionality: Skin brightening, anti-inflammatory, skin renewal
• FDA UNII: H9G9QJT7E2
• Solubility: Water-soluble
• Usage Rate: 1%–5% in emulsions, gels, or serums

Where to Buy Tetrapeptide-30 or Raw Material?

Looking for where to buy Tetrapeptide-30 or source Tetrapeptide-30 raw material for formulation? We offer high-purity, cosmetic-grade Tetrapeptide-30 perfect for R&D, private label manufacturing, or DIY skincare.

Why Choose Tetrapeptide-30?

Tetrapeptide-30 is more than just a skin-brightening agent. Its smart anti-inflammatory mechanism, combined with firming and anti-aging benefits, makes it an exceptional choice for advanced multifunctional skincare. Whether you’re addressing dark spots, aging, or skin sensitivity, this peptide delivers real results without irritation.

What is Tripeptide-10 Citrulline?

Tripeptide-10 Citrulline, marketed as Decorinyl®, is a biomimetic peptide that mimics the function of decorin, a key protein that regulates collagen fibril formation. By restoring collagen’s natural structure, it helps rebuild skin firmness, improve elasticity, and reduce signs of aging such as wrinkles and sagging skin.

Tripeptide-10 Citrulline (Decorinyl) Benefits

• Boosts Collagen Structure: Regulates collagen fibril diameter for better organization and integrity.
• Tripeptide-10 for Wrinkle Reduction: Smooths fine lines and deep wrinkles by improving skin’s biomechanical properties.
• Decorinyl Peptide for Skin Firmness: Enhances elasticity and firmness by supporting functional collagen remodeling.
• Improves Skin Texture: Visibly softens, smooths, and rejuvenates rough or tired-looking skin.
• Clinical-Grade Results: Shown to improve skin suppleness by up to 54% within 28 days in clinical studies.

Decorinyl vs Hyaluronic Acid Filler

Unlike hyaluronic acid fillers that add volume temporarily, Decorinyl® targets the skin’s foundation structure by restoring collagen quality, making it a natural and long-lasting approach to firm, youthful-looking skin.

How It Works

• Collagen Fibril Regulation: Acts like natural decorin to regulate collagen fiber formation, ensuring even spacing and improved tensile strength.
• Restores Skin Resilience: Improves skin’s biomechanical function by stabilizing and organizing collagen networks.
• Compatible with Skin Biology: Works in harmony with skin’s natural repair processes.

Functions

• Anti-aging Peptide
• Firming Agent
• Collagen Support Ingredient
• Skin Texture Enhancer

INCI & Technical Details

• INCI: Tripeptide-10 Citrulline
• Trademark Name: Decorinyl®
• Recommended Use Level: 1%–5%
• Form: Water-soluble peptide
• Application pH Range: 4.5–7

Ideal Applications

Use in:

• Anti-aging creams and firming serums
• Wrinkle reduction and elasticity-boosting products
• Eye contour and neck firming formulations
• Skin barrier and collagen support treatments

Where to Buy Decorinyl Peptide?

Looking for where to buy Decorinyl peptide? We offer high-quality, cosmetic-grade Tripeptide-10 Citrulline raw material for research, skincare formulation, and product development.

Why Choose Tripeptide-10 Citrulline (Decorinyl®)?

Decorinyl® offers a science-backed, non-invasive alternative to traditional fillers. By targeting the architecture of collagen, it delivers long-term benefits in skin firmness, elasticity, and wrinkle reduction. Ideal for formulators seeking an advanced anti-aging peptide that works with the skin—not against it.

Copper Tripeptide-1 (GHK-Cu) – Advanced Anti-Aging & Hair Growth Peptide

Copper Peptide (GHK-Cu) is a naturally occurring tripeptide complex that binds copper ions and plays a pivotal role in skin rejuvenation, wound repair, and hair follicle stimulation. Known in skincare and dermatological science for over four decades, Copper Tripeptide-1 (GHK-Cu) delivers clinically proven benefits in anti-aging, skin firmness, and hair regrowth.

Copper Peptide (GHK-Cu) Skin Rejuvenation

The peptide sequence Gly-His-Lys bonded with copper ions revitalizes the skin through multiple mechanisms:

• Stimulates collagen and elastin production
• Improves skin firmness and elasticity
• Reduces wrinkles and fine lines
• Supports skin healing and regeneration

These effects make Copper Tripeptide-1 benefits for wrinkles comparable to some traditional actives like retinol—but with less irritation, offering a gentler yet effective alternative in the copper peptide vs retinol anti-aging conversation.

How GHK-Cu Works

GHK-Cu binds to copper ions and triggers:

• Fibroblast attraction & activation
• Synthesis of extracellular matrix proteins
• Angiogenesis (new blood vessel formation)
• Reduction of inflammation & oxidative stress
• Skin tone improvement via hyperpigmentation reduction

Copper Tripeptide in Skincare

Used widely in anti-aging skincare, GHK-Cu improves:

• Skin texture and hydration
• Firmness and plumpness
• Tone uniformity (reducing hyperpigmentation)
• Wound healing and scar reduction

It’s found in advanced serums, eye creams, and GHK-Cu peptide-infused moisturizers.

GHK-Cu Peptide Hair Growth Stimulant

GHK-Cu also acts as a hair growth stimulant, making it a key ingredient in:

• Hair thickening serums
• Post-transplant healing products
• Scalp rejuvenation treatments

Benefits include:

• Increased follicle size
• Enhanced hair density
• Improved scalp health

Product Specifications

• INCI Name: Copper Tripeptide-1 (GHK-Cu)
• CAS Number: 89030-95-5
• Molecular Formula: C₁₄H₂₃CuN₆O₄
• Molecular Weight: 340.384 g/mol
• Sequence: Gly-His-Lys·Cu
• FDA UNII: 6BJQ43T1I9
• Synonyms: Prezatide Copper, GHK-Cu Complex
• Related Peptides: Tripeptide-1, Bis(Tripeptide-1) Copper Acetate, Copper Tripeptide Palmitamide

Where to Buy Copper Peptide GHK-Cu

Looking for where to buy Copper Peptide GHK-Cu? Our high-purity GHK-Cu is available for cosmetic formulation, research use, or personal skincare/haircare needs. Trusted by formulators and dermatologists alike.

Functions & Applications

• Anti-aging and wrinkle care
• Skin rejuvenation and hydration
• Hair growth stimulation
• Wound healing and tissue repair
• Post-procedure recovery

Overview

Carnosine (β-alanyl-L-histidine) is a naturally occurring dipeptide with potent antioxidant and anti-glycation properties, making it a valuable ingredient in anti-aging skincare products.

Mechanism of Action

Carnosine's benefits stem from its ability to:

• Scavenge ROS and RCS: It neutralizes reactive oxygen and carbonyl species, protecting skin cells from oxidative stress.
• Prevent Protein Glycation: It inhibits the damaging process of glycation in the extracellular matrix (ECM), preserving the skin's structure and function.
• React with Aldehydes: It binds to low-molecular-weight aldehydes, preventing their harmful effects on skin proteins.
• Prevent Cross-linking: It inhibits the cross-linking of macromolecules like collagen and DNA, maintaining skin firmness and elasticity.
• Chelate Heavy Metals: It acts as a chelating agent, removing harmful heavy metal ions from the skin.
• Boost Regeneration: It supports the skin's natural regenerative processes, contributing to wound healing.

Applications

Carnosine's versatility makes it suitable for a range of skincare applications, including anti-aging creams, serums, and wound-healing ointments (a use dating back to the 1940s).

Specifications

• Sequence: β-alanyl-L-histidine
• Molecular Formula: C₉H₁₄N₄O₃
• Molecular Weight: 226.23 g/mol
• CAS #: 305-84-0
• EINECS #: 206-169-9
• FDA UNII: 8HO6PVN24W

Functions

• Anti-aging
• Antiglycation
• Antioxidant
• Skin conditioning

What is Hexapeptide-10?

Hexapeptide-10, known under the trade name Serilesine®, is a synthetic peptide that mimics a specific adhesion sequence of Laminin, a key protein in the skin's dermo-epidermal junction (DEJ). It is used to strengthen the skin structure, support scar healing, and improve skin regeneration.  The amino acid sequence of Hexapeptide-10 is Ser-Asp-Gly-Pro-Arg-Pro.

Hexapeptide-10 (Serilesine) Benefits

• Skin Firmness & Redensification: Promotes adhesion between keratinocytes and fibroblasts, improving skin density and compactness.
• Supports Skin Regeneration: Stimulates Laminin-5 and Integrin-α6 production, reinforcing the dermo-epidermal junction.
• Serilesine Anti-Aging Peptide Uses: Reduces visible signs of aging by improving skin’s internal anchoring system.
• Serilesine Peptide for Scar Healing: Encourages better cellular adhesion and organization, which helps in scar tissue remodeling and healing.
• Boosts Cellular Activity: Enhances keratinocyte proliferation by 38% and fibroblast activity by 75%, aiding tissue repair and skin rejuvenation.

How It Works

• Mimics Laminin Function: Repeats the adhesion sequence of Laminin protein to support cell-to-cell communication and epidermal-dermal anchoring.
• Restores DEJ Integrity: Promotes hemidesmosome formation and strengthens the dermo-epidermal junction, reducing signs of skin sagging.
• Boosts ECM Proteins: Stimulates the expression of key structural proteins like Laminin-5 and α6-Integrin, critical for youthful, resilient skin.

Technical Information

• INCI Name: Hexapeptide-10
• Trade Name: Serilesine®
• Form: Water-soluble peptide
• Recommended Use Level: Up to 0.005%
• Applications: Emulsions, gels, serums, creams

Functions

• Anti-aging peptide
• Skin regeneration support
• Scar repair and skin restructuring
• Skin firming and redensifying agent

Ideal Uses

• Anti-aging serums and creams
• Skin tightening and firming treatments
• Post-scar care formulations
• Regenerative skincare products

Where to Buy Serilesine Peptide?

Searching for where to buy Serilesine peptide? We provide high-purity Hexapeptide-10 raw material for cosmetic formulation, skincare manufacturing, and R&D use.

Why Choose Hexapeptide-10?

Hexapeptide-10 (Serilesine®) is a scientifically backed, multifunctional peptide that enhances skin firmness, aids in scar healing, and stimulates skin regeneration at the cellular level. Ideal for anti-aging and reparative skincare lines, it delivers visible results by reinforcing the skin’s structural proteins naturally and safely.

Overview

Decapeptide-4, also known as CG-IDP2, is a synthetic peptide that mimics the effects of Somatomedin growth factors. Its primary applications are in skincare and haircare, where it promotes collagen and elastin production, improves skin texture, reduces wrinkles, and stimulates hair growth. It also shows promise as an anabolic peptide for body contouring.

Mechanisms of Action

Decapeptide-4 exerts its effects through several key mechanisms:

• Collagen and Elastin Stimulation: Enhances the production of these structural proteins, leading to firmer, more elastic skin.
• Cell Proliferation: Boosts the proliferation of keratinocytes and fibroblasts, accelerating skin cell renewal and repair. This effect is demonstrably seen within 72 hours of application.
• Anti-aging Effects: Reduces the appearance of fine lines and wrinkles by supporting the generation of new skin cells.
• Anabolic Effects (injections): Inhibits triglyceride production and restructures subcutaneous adipose tissue, potentially aiding in body contouring.
• Hair Growth Stimulation: Activates hair papilla stem cells, promoting the growth of strong, healthy hair.

Applications

Decapeptide-4 is a versatile ingredient used in:

• Skincare: Anti-aging creams, serums, and lotions designed to improve skin elasticity, firmness, and texture.
• Body Contouring: Injections targeting subcutaneous fat tissue for body sculpting.
• Haircare: Shampoos, conditioners, and treatments aimed at stimulating hair growth and improving hair health.

Functions

• Anti-aging
• Firming
• Smoothing
• Slimming
• Regeneration booster
• Hair growth stimulator
• Skin conditioning

Chemical Info:

• Molecular Formula: C₄₂H₆₅N₁₃O₁₅
• Amino Acid Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Arg-Pro-Ala-Asp
• Molecular Weight: 819.9 g/mol 
• Synonyms: CG-IDP2

Discover the Secret to Radiant Skin with Acetyl Heptapeptide-4

Unveil a healthier, revitalized complexion with Acetyl Heptapeptide-4, a cutting-edge synthetic peptide known by the trade name Fensebiome™. This remarkable peptide, formulated with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala, is designed to restore and maintain the delicate balance of your skin's microbiota.

The Urban Skin Challenge

In our fast-paced urban environments, our skin can lose vital aspects of its natural microflora, leading to sensitivity, irritation, and inflammation. Research has shown that those living closer to nature benefit from a richer and more diverse microbiota, resulting in robust skin defenses.

The Probiotic Power of Fensebiome™

Fensebiome™ promotes the growth of beneficial bacteria, acting as a powerful probiotic that not only soothes and protects but also enhances your skin's natural defenses against harmful microbes. Experience reduced sensitivity, diminished discomfort, and a decrease in scaling and irritation. This innovative ingredient also boosts hydration, revealing a smooth, healthy, and radiant appearance.

Strengthening Your Skin Barrier

Moreover, Acetyl Heptapeptide-4 strengthens dermal cell cohesion, improving your skin’s barrier integrity while actively supporting its immune response to harmful bacteria. This makes Fensebiome™ an exceptional choice for modern face and body care routines. Its significant probiotic action is particularly effective in hand sanitizers, helping to restore a natural microbiota balance while providing hydration and protection.

Product Details

• Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala
• Molecular Formula: C37H64N14O14S
  M.W.: 961.06 g/mol
  
• CAS Number: 1459206-66-6
• Synonyms: Fensebiome™
• Functions: Probiotic, Hydrating, Barrier Enhancer, Humectant, Skin Conditioning

Embrace the Beauty of Balanced Skin

Embrace the beauty of balanced skin with the transformative power of Acetyl Heptapeptide-4!

Overview

Acetyl Tetrapeptide-11 (Ac-Pro-Pro-Tyr-Leu-NH2) is an active peptide that combats the visible signs of skin aging. It targets the epidermis, improving its cohesion, strength, and overall appearance, resulting in smoother, firmer skin.

Mechanism of Action

The skin aging process is significantly influenced by the reduction of Syndecan-1 (a proteoglycan vital for epidermal cohesion) and Collagen XVII (a protein crucial for dermo-epidermal junction adhesion). Acetyl Tetrapeptide-11 works by stimulating the synthesis of both these molecules. This action reinforces epidermal cohesion and improves adhesion between the dermis and epidermis.

Benefits

• Improved skin elasticity and firmness.
• Enhanced epidermal cohesion.
• Strengthened dermo-epidermal junction adhesion.
• Refined skin texture.

Applications

Acetyl Tetrapeptide-11 is ideal for use in anti-aging face creams and skincare products formulated for mature skin. Its efficacy has been demonstrated in studies on individuals over 65.

Specifications

• Synonyms: SYNIORAGE™ LS 9748, SYNIORAGE™ PW LS 9847
• Sequence: Ac-Pro-Pro-Tyr-Leu-NH2
• Molecular Formula: C₂₇H₃₈N₄O₇
• Molecular Weight: 530.6 g/mol
• CAS #: 928006-88-6
• FDA UNII: 0R3VC3BV8I

Functions

• Anti-aging
• Firming
• Skin conditioning

Harnessing the Power of Circadian Rhythms for Radiant Skin

Chronolux® Tripeptide-32 (Ser-Thr-Pro-NH2) is a groundbreaking synthetic peptide that leverages the body's natural circadian rhythms to protect and revitalize the skin. Unlike traditional skincare approaches, Chronolux® works with your skin's natural processes, optimizing its defense mechanisms against daily environmental stressors.

How Chronolux® Tripeptide-32 Works:

This unique peptide directly activates the CLOCK and PER1 genes within keratinocytes – the key cells of the epidermis. This activation triggers a cascade of beneficial effects:

• Enhanced DNA Repair: Stimulates the production of enzymes crucial for repairing DNA damage caused by UV exposure, pollution, and other environmental aggressors.
• Improved Cell Viability and Longevity: Promotes healthier, longer-lasting skin cells, contributing to a youthful appearance.
• Strengthened Skin Barrier: Supports the skin's natural protective barrier, enhancing its resilience against external damage.

Key Benefits:

• Protective: Shields against environmental damage.
• Photoprotective: Helps protect against sun-induced damage.
• Anti-aging: Promotes a more youthful and radiant complexion.
• Skin conditioning: Improves overall skin health and texture.

Chemical Info:

• CAS#: 1185583-20-3
• Sequence: Ser-Thr-Pro-NH2 (or STP-NH2)
• Molecular Weight: 302.33 g/mol
• Molecular Formula: C₁₂H₂₂N₄O₅
• Synonyms: L-Prolinamide, L-seryl-L-threonyl-; (S)-1-(L-seryl-L-threonyl)pyrrolidine-2-carboxamide; L-Seryl-L-threonyl-L-prolinamide; Chronolux

Argireline® concentrated solution is a multifunctional peptide designed and produced following green chemistry principles that represents an evolution of Argireline® peptide (Acetyl Hexapeptide-8). The ingredient shows an amplified efficacy in regulating the pre-synaptic mechanism behind expression wrinkles, but it also acts at the post-synaptic level to produce softer muscle contraction and improved muscle relaxation after an expression. The peptide also minimizes the senescence process in all the skin layers.

Benefits

• Peptide shows an amplified efficacy in regulating the skin tightening properties
• Works through a unique mechanism which makes the skin looks firm and tight
• Peptide minimizes the senescence process in all the skin layers
• Can reduce the appearance of superficial facial lines and wrinkles with regular use
• In studies appearance of wrinkles was reduced significantly
• Can be combined with Tripeptide-5, Collagen Booster Peptide and Teprenone for combination products

Application & Use

The Argireline Concentrated Solution is formulated as stock solution to be added to other skincare base, e.g, creams, lotions, & gels, sun care & after sun products to craft anti-aging and anti-wrinkle cosmetics of your own.

Add to aqueous phase of formulas best <40°C/100°F (creams, lotions, gels etc). Typical use level is 2-5%. For external use only.

Qualitide stands by you to support your DIY needs.

Ingredients

• Argireline (Acetyl Hexapeptide-8)
• Vegetable Glycerin
• Propylene Glycol
• Phenoxyethanol
• Ethylhexylglycerin 
• Aqua

Overview

α-Endorphin (also known as alpha-endorphin or LPH(61-76)) is an endogenous opioid peptide naturally produced in the pituitary gland and central nervous system. This 16-amino acid peptide plays a significant role in pain modulation, stress response, and emotional regulation.

Molecular Properties

• CAS Number: 59004-96-5
• Molecular Weight: 1745.95
• Molecular Formula: C₇₇H₁₂₀N₁₈O₂₆S
• Purity: ≥97%

Mechanism of Action

α-Endorphin exerts its effects by binding to mu, delta, and kappa opioid receptors throughout the nervous system. This binding activates inhibitory G-proteins, leading to a cascade of events:

• Reduced cAMP levels: Decreased levels of cyclic adenosine monophosphate.
• Calcium channel closure: Reduced influx of calcium ions into neurons.
• Potassium channel opening: Increased efflux of potassium ions from neurons.

These changes result in decreased neurotransmitter release, ultimately modulating pain perception and emotional responses.

Research Applications

α-Endorphin is a valuable tool in neuroscience research, allowing scientists to study:

• Endogenous opioid system: The body's natural pain management and stress response mechanisms.
• Pain pathways: Understanding the neurochemical processes underlying pain perception.
• Stress response: Investigating the role of opioids in coping with stress.
• Reward systems: Exploring the involvement of opioids in reward and motivation.

Research with α-endorphin contributes significantly to advancements in neurobiology and endocrinology, enhancing our understanding of the body's natural homeostasis and stress management capabilities.

Conclusion

α-Endorphin's role as an endogenous opioid peptide is crucial to the body's natural pain management and stress response systems. Further research using α-endorphin continues to unlock valuable insights into these complex biological processes.

Eyeliss contains three active ingredients – a plant-based extract that helps reduce puffiness by reducing fluid buildup beneath the eyes and two natural peptides that combat dark eye circles while boosting skin’s elasticity, both of which help reduce fine lines and wrinkles, creating a more youthful appearance. Qualitide ™ combines three active ingredients into a ready-to-use formula that can be added to your eye cream or serum products.

Eyeliss™ helps reduce puffiness by reducing fluid buildup beneath the eyes.
Eyeliss™ can be added directly to a lotion base like our Aloe Gel Base to create a high-end eye treatment.

Clear medium yellow liquid. May be used at a rate of up to 3%

Eyeliss™ can be added directly to a lotion base like our Aloe Gel Base to create a high-end eye treatment.

Eyeliss™ helps prevent puffiness and reduces bags under the eyes by using three active molecules: hesperidin methyl chalcone, dipeptide VW and lipopeptide Pal-GQPR.

This product is recommended for use in creams, gels, lotions and other applications intended to reduce puffy eyes and smooth the appearance of fine lines by firming and toning the skin.

Improves firmness and elasticity while decreasing the inflammatory effects of tiredness and hypertension as well as the natural, inevitable effects of ageing which contribute to the formation of bags under the eyes.