QUALITIDE

COG1410 ApoE Mimetic Peptide | Neuroprotective & Anti-Inflammatory Research Peptide

Product Name: COG1410
 Synonym: ApoE Mimetic Peptide
 CAS Number: 878009-24-6
 Molecular Formula: C₆₄H₁₂₁N₂₁O₁₄
 Molecular Weight: 1408.78 g/mol
 Sequence: Ac-AS-{Aib}-LRKL-{Aib}-KRLL-NH₂
 Purity: ≥98%
 Appearance: Solid, white to off-white

What is COG1410?

COG1410 ApoE mimetic peptide is a synthetic peptide derived from the receptor-binding region of apolipoprotein E (ApoE). It is structurally enhanced with alpha-aminoisobutyric acid (Aib) residues for increased stability and bioactivity. This research peptide is known for its neuroprotective and anti-inflammatory effects, making it ideal for preclinical investigation into brain health, traumatic brain injury (TBI), stroke, and neurodegenerative diseases.

COG1410 Peptide Anti-Inflammatory Uses

●     Neuroinflammation Reduction: COG1410 has demonstrated the ability to modulate inflammation in brain tissues following traumatic brain injury and ischemic events.

●     Oxidative Stress Control: It reduces oxidative damage and cellular apoptosis in neuronal environments.

●     Cognitive Recovery Support: Shows promise in improving neurological outcomes post-TBI in animal models.

●     Immunomodulatory Effects: Helps balance pro- and anti-inflammatory cytokines in the central nervous system.

COG1410 for Brain Health Research

Used extensively in neurological research, COG1410 plays a key role in investigating:

●      Traumatic Brain Injury (TBI)

●      Cerebral ischemia and stroke

●      Alzheimer’s and neurodegenerative conditions

●      Neuroimmune interactions

Its design enables crossing of the blood-brain barrier, a vital feature for brain-targeted therapeutic research.

COG1410 vs COG112 Peptide Comparison

While both peptides are derived from ApoE and share anti-inflammatory and neuroprotective characteristics:

●     COG112 includes a cell-penetrating peptide (CPP) sequence to enhance intracellular delivery.

●     COG1410, with its Aib-modified backbone, offers increased resistance to enzymatic degradation and sustained bioactivity.

Researchers may choose COG1410 for longer-lasting effects and targeted action in neuroinflammatory models.

Storage & Handling

●      Powder:

○        −80°C: 3 years

○        −20°C: 2 year

●      In Solution (sealed, nitrogen-protected):

○        −80°C: 1 year

○        −20°C: 6 months

●     Shipping: Room temperature (within continental US)

Specifications

Where to Buy COG1410 Peptide

Where to buy COG1410 peptide online? We provide high-purity, research-grade COG1410 ApoE mimetic peptide, available in bulk or small quantities for laboratories, universities, and R&D professionals. Ideal for formulations in brain injury, stroke, and neuroinflammation research.

COG133 ApoE Mimetic Peptide – Neuroprotective & Anti-Inflammatory Agent

COG133 is a synthetic ApoE mimetic peptide derived from the receptor-binding region of apolipoprotein E. It exhibits potent anti-inflammatory, neuroprotective, and cognitive-supportive effects, making it a key research peptide in neurodegenerative disease models and neuroimmune regulation.

COG133 Peptide for Cognitive Health

COG133 acts via the low-density lipoprotein receptor-related protein (LRP) pathway and demonstrates promising applications in neurobiology, especially:

• Suppressing neuroinflammation
• Reducing demyelination
• Supporting cognitive resilience

In studies on experimental autoimmune encephalomyelitis (EAE)—a model of multiple sclerosis—COG133 significantly reduced clinical symptoms and spinal cord inflammation. This highlights its relevance for cognitive health and neuroinflammatory research.

COG133 Anti-Inflammatory Effects

• Modulates CNS inflammation by targeting immune cell infiltration
• Reduces pro-inflammatory cytokines, helping preserve myelin integrity
• Shows activity as a non-competitive α7 nicotinic acetylcholine receptor antagonist with an IC₅₀ of 445 nM
• Useful in inflammation-related neurological studies

COG133 vs COG112 Peptide Comparison

While both are derived from ApoE peptides, COG133 and COG112 differ in design and application:

• COG133: LRP-dependent pathway, potent anti-inflammatory and cognitive protection
• COG112: COG133 + penetratin sequence for improved BBB permeability
  For applications not requiring direct CNS delivery, COG133 peptide offers a cleaner, focused mechanism of action.

Technical Specifications

• Peptide Name: COG133
• Sequence: Ac-LRVRLASHLRKLRKRLL-NH₂
• Molecular Formula: C₉₇H₁₈₁N₃₇O₁₉
• Molecular Weight: 2169.73 g/mol
• CAS Number: 514200-66-9
• PubChem CID: 16201427
• Purity: ≥95% (HPLC-verified)
• Storage: –20°C (long-term)

Applications

• Neuroinflammation research
• Multiple sclerosis models (EAE)
• Cognitive impairment and memory studies
• ApoE receptor pathway investigations
• Anti-inflammatory peptide drug development

Buy COG133 Peptide Online

Looking for high-purity COG133 ApoE mimetic peptide? We offer lab-tested, research-grade material ready for:

• Academic and pharmaceutical R&D
• Preclinical neuroimmune and cognitive health research
• In vitro and in vivo experiments

Buy COG133 peptide online today and support your next breakthrough in peptide-based neuroscience.

Tripeptide-29 is a synthetic biomimetic peptide that significantly improves collagen synthesis promoting wrinkle reduction, firming, and skin plumping. It is known under the trademark AC Collagen Prepeptide PF.

Collagen is a long-chain polymer made of short monomeric repeats that are generally made up of three amino acids in sequences. Collagen subunit almost always follows the pattern of Gly-Pro-X or Gly-X-Hyp. Tripeptide-29 is a Gly-Pro-Hyp peptide, making it a perfect synthetic analogue of common collagen building blocks. Thanks to a small molecular weight of 285 D, Tripeptide-29 exhibits increased bioavailability and easily penetrates deeper layers of the skin. Reaching dermal fibroblasts, stimulates those cells enhancing collagen synthesis activity.

Increased collagen production improves DHJ (dermal-epidermal junction) integrity and scaffolding matrix. Tripeptide-29 is a safe and effective ingredient for anti-aging preparations formulated to boost collagen production and expose a youthful, healthy, and radiant appearance. It is usually used in 0.1 – 1.0% concentration.

Hyaluronic Acid Hydrating Serum: Anti-Aging Moisture Boost for Plump, Youthful Skin

Product Overview:

Experience the powerful hyaluronic acid benefits for skin hydration with our premium-grade Hyaluronic Acid Hydrating Serum. This ultra-lightweight formula is expertly designed to replenish moisture, support elasticity, and minimize the appearance of fine lines and wrinkles. Whether you’re new to HA or upgrading your routine, this is one of the best hyaluronic acid serums for wrinkles and everyday skin rejuvenation.

Key Features & Benefits

●     Advanced Hydration: HA binds up to 1000x its weight in water to deeply hydrate and plump skin.

●     Wrinkle Smoothing: Fills in fine lines and restores youthful texture.

●     Skin Conditioning: Softens, smooths, and improves skin tone.

●     Anti-Inflammatory Action: Helps calm redness and irritation.

●     Photoaging Defense: Shields skin from environmental oxidative stress.

●     Regeneration Boost: Supports skin recovery and healing.

●     Non-Greasy Finish: Ideal for all skin types, including oily and sensitive.

Why Hyaluronic Acid Works

Hyaluronic acid is a naturally occurring glycosaminoglycan found in your skin’s extracellular matrix. It acts as a humectant that attracts and retains moisture, preventing dermal dehydration, sagging, and wrinkle formation. As you age, natural HA levels decrease leading to dryness and volume loss. This serum restores your skin’s hydration reservoir and promotes collagen and elastin production, delivering a firmer, more youthful appearance.

Hyaluronic Acid vs Collagen for Anti-Aging

While collagen provides structure, hyaluronic acid is the hydration engine. HA ensures that skin stays supple enough for collagen to remain elastic and effective. Used together, they form the ultimate anti-aging duo boosting volume, reducing wrinkles, and enhancing skin resilience.

Hyaluronic Acid Injection vs Topical

HA injections are often used for deeper wrinkle correction and facial volume restoration, but topical hyaluronic acid hydrating serum offers powerful daily moisture support without needles. Our serum uses multi-molecular weight hyaluronic acid to penetrate different skin layers hydrating from the surface down to deeper tissues.

Full Ingredient Profile

●     INCI: Sodium Hyaluronate

●     CAS Number: 9004-61-9

●     EINECS: 232-678-0

●     FDA UNII: S270N0TRQY

FAQ

Q: What are the top hyaluronic acid benefits for skin hydration?
 A: It locks in moisture, prevents transepidermal water loss, and helps smooth and firm the skin—delivering visibly plumper and fresher skin.

Q: How does this compare to injections?
 A: While injections offer instant volume, this topical serum offers cumulative, needle-free benefits with daily use.

Why Choose This Product

●      Dermatologist-tested

●      Clean formulation, no artificial fragrance

●      Paraben-free, cruelty-free, vegan

●      Made in GMP-certified facility

Your Daily Dose of Hydration Starts Here

Elevate your skincare with one of the best hyaluronic acid serums for wrinkles. Whether you're exploring hyaluronic acid vs collagen for anti-aging or choosing between hyaluronic acid injection vs topical solutions, this product offers an effective, science-backed solution to deeply hydrate, smooth, and rejuvenate your skin.

What Is PT-141? 

PT-141, also called bremelanotide, is sometimes referred to as the female Viagra because the peptide was previously investigated in Phase IIb human clinical trials for use in treating female hypoactive sexual desire disorder (HSDD). PT-141 binds to the melanocortin-4 and 1 receptors, improving sexual arousal and the immunological system. 

PT-141 (Bremelanotide) Nasal Spray is an FDA-approved peptide designed specifically for the treatment of erectile dysfunction or impotence in men and hypoactive sexual desire disorder (HSDD) in women.  It is the first and only melanocortin receptor agonist approved by the FDA for the treatment of HSDD in premenopausal women. PT-141 targets the central nervous system directly to improve libido and pleasure. It’s an effective and powerful enhancer for both your mood and your senses. With regular use, PT-141 supports a more vibrant and satisfying intimate experience. This convenient nasal spray formulation ensures rapid absorption, making PT-141 a popular choice for those looking to boost libido naturally.

Why You Will Love It:

Potential Benefits:

• Enhances Sexual Arousal: PT-141 is known for its ability to improve sexual desire and satisfaction in both men and women, offering a natural solution for libido enhancement.

• Supports Erectile Function: For men, PT-141 may help improve erectile function by stimulating the central nervous system, without directly affecting blood flow as traditional ED treatments do.

• Boosts Sexual Confidence: By enhancing arousal and performance, PT-141 can help individuals feel more confident and reduce anxiety related to sexual activity.

• Natural Libido Enhancement: PT-141 works with the body’s natural processes to improve sexual desire and responsiveness, making it an excellent option for those seeking non-hormonal support for sexual health.

Positive Impact of Nasal Spray Delivery:

Using PT-141 peptide as a nasal spray offers several advantages that can enhance its benefits:

• Rapid Absorption, Fast Acting: Nasal administration allows PT-141 to be rapidly absorbed through the nasal mucosa and enter the bloodstream, leading to faster onset of action compared to other administration routes. This ensures timely delivery of PT-141 to target tissues, maximizing its effects on sexual function.

• Easy Use, No Needles! Nasal spray delivery provides a discreet and convenient method of PT-141 supplementation, allowing individuals to administer the peptide easily and discreetly, without the need for injections or oral medications. This enhances compliance and makes PT-141 more accessible to individuals seeking to improve their sexual health.
• Targeted Delivery to the Brain: The nasal route provides direct access to the brain via the olfactory and trigeminal nerves, allowing PT-141 to exert its effects on sexual desire and arousal more efficiently. This targeted delivery enhances the potency of PT-141 in enhancing sexual function and promoting a satisfying sexual experience.

Possible Side Effects:

PT-141 has been extensively researched and found to be safe and well-tolerated. The most common adverse reaction are:

• Nausea
• Flushing
• Headaches
• Vomiting

Warning: PT-141 should not be used by patients with uncontrolled hypertension or known cardiovascular disease and comes with a number of warning and precautions.

This product is for research purpose only, not intended nor approved for treatment of any human diseases.

Decapeptide-12 is a synthetic peptide that is composed of 10 amino acids. Its developers and subsequent researchers have suggested that Decapeptide-12 may potentially inhibit melanin production in the skin by suppressing the activity of tyrosinase, an enzyme involved in the synthesis of melanin.

Decapeptide-12 does not appear to mimic any naturally occurring peptide. Rather, it was designed and synthesized to exhibit specific properties. Decapeptide-12 is primarily researched in reducing melanin production and hyperpigmentation. It has also been studied for its potential impact on cell growth, differentiation, and mitigating cell aging. However, more research is needed to fully understand the potential properties and results of Decapeptide-12 experiments in these contexts.

Chemical Info

• Molecular Formula: C₆₅H₉₀N₁₈O₁₇
  Molecular Weight: 1311.46 g/mol
• CAS#: 137665-91-9
• Sequence: H-YRSRKYSSWY-OH
• Synonyms: Lumixyl™

Functions

• Skin whitening agent
• Hair bleaching
• Skin conditioning

Overview and Mechanisms of Action

As mentioned, Decapeptide-12 is posited to work primarily by inhibiting melanin synthesis, aka melanogenesis. Melanin synthesis is suggested to be a complex biochemical pathway that may occur within specialized cells in the skin called melanocytes. Tyrosinase is posited to play a pivotal role in this pathway as it appears to catalyze the first two steps in melanin production: the hydroxylation of tyrosine to DOPA (3,4-dihydroxyphenylalanine) and the oxidation of DOPA to DOPAquinone. These reactions are suggested to be essential for the subsequent production of eumelanin and pheomelanin, the two main types of melanin pigments that determine skin, hair, and eye color and may protect against UV radiation. As mentioned, Decapeptide-12 may act by potentially inhibiting tyrosinase activity. While the precise molecular mechanisms are complex and involve multiple pathways, the basic understanding is that Decapeptide-12 may bind to specific sites on the tyrosinase enzyme or its mRNA, thereby blocking the enzyme's ability to catalyze the aforementioned critical reactions in melanin synthesis. This inhibition could occur through direct interaction with the enzyme, leading to a change in its conformation and reducing its catalytic efficiency. Alternatively, Decapeptide-12 might interfere with the enzyme's gene expression, lowering the amount of functional tyrosinase produced in the melanocytes.

Research and Clinical Studies

Decapeptide-12 and Melasma

One clinical study aimed to evaluate the potential of Decapeptide-12 in test subjects with moderate to severe melasma, solar lentigines, periocular lines, and wrinkles.⁽¹⁾ This 24-week experiment reported apparent improvements in all of the reported facial conditions among the 25 subjects, with sustained impact.

Another clinical trial investigated the potential of Decapeptide-12 on mild-to-moderate melasma in 33 test subjects over 16 weeks.⁽²⁾ Results suggested a visible reduction in the appearance of melasma.

Furthermore, one study reported a complete clearance of melasma in 25% of subjects after six weeks of Decapeptide-12 presentation.⁽³⁾Decapeptide-12 also was reported by the researchers to exhibit an apparent impact in test subjects with the Fitzpatrick phototype IV skin type and moderate recalcitrant melasma completed.⁽⁴⁾ Subjects with Fitzpatrick skin type IV are reportedly some of the most common melasma sufferers. The researchers concluded that: “All […] demonstrated statistically significant improvement in the appearance of melasma and overall facial aesthetics.”

Decapeptide-12 and Post-inflammatory Hyperpigmentation

A clinical case study on pigmented skin (Fitzpatrick skin type IV) indicated that Decapeptide-12 may possibly accelerate the clearance of post-inflammatory hyperpigmentation compared to placebo.⁽⁵⁾ The researchers suggest this might be due to the tyrosinase-inhibiting potential of Decapeptide-12.⁽⁶⁾

Decapeptide-12 and Solar Lentigo

One study evaluated the impact of Decapeptide-12 in the form of hyperpigmentation called solar lentigines caused by chronic photodamage.⁽⁷⁾ The results reported that 38.5% of the models evaluated appeared to have achieved complete clearance, and all subjects appeared to exhibit some improvement. Furthermore, 30.7% of the models were reported to improve from a moderate degree of photodamage to a milder degree, 15.4% improved from a severe degree to a moderate degree, and another 15.4% improved from a severe degree to a milder degree after 24 weeks.

Decapeptide-12 and Cell Aging

Sirtuins are a family of genes involved in various cellular processes. They are believed to regulate cellular metabolism, DNA repair, inflammation, and stress resistance. One of the most well-known sirtuins is SIRT1, which has been suggested to regulate various biological pathways, such as glucose metabolism, lipid metabolism, and cellular stress responses. Studies have also suggested that SIRT1 may be involved in extending the lifespan in certain model organisms. One of the most promising compounds is resveratrol, found in red wine, and has been suggested to activate SIRT1 in some studies.

One study looked at the potential of Decapeptide-12 on sirtuin gene expression levels in keratinocyte progenitors.⁽⁸⁾ The researchers used RT-PCR to measure the impact of Decapeptide-12 on seven Sirtuin genes and cellular viability and proliferation after 72-hour incubation with various concentrations of Decapeptide-12. The results suggested that Decapeptide-12 possibly increased the transcription of several Sirtuin genes, including SIRT1, SIRT3, SIRT6, and SIRT7, with reportedly reduced cytotoxicity. The researchers reported that “ decapeptide-12 increased transcription of SIRT1 by 141 ± 11% relative to control cells, whereas levels of SIRT3, SIRT6, and SIRT7 were increased by 121 ± 13%, 147 ± 8% and 95± 14%, respectively.”

SIRT1, with a reported increase in transcription by 141 ± 11% may enhance cellular resilience against oxidative stress and inflammation, possibly delaying aging processes on a cellular level. The apparent increases in SIRT3 (121 ± 13%) and SIRT6 (147 ± 8%) transcription levels further amplify the possible research outcomes. SIRT3's potential involvement in mitochondrial function and energy metabolism suggests that decapeptide-12 might enhance mitochondrial efficiency and antioxidant capacity. Similarly, SIRT6 is possibly associated with DNA repair, telomere maintenance, and inflammation regulation. Its potential upregulation might contribute to improved genomic stability and reduced inflammation, potentially further decelerating the aging process in cells. While the reported increase in SIRT7 transcription (95 ± 14%) appears less pronounced, it may still indicate potential influence on nucleolar functions, including ribosome biogenesis and stress sensing. This subtle modulation might also contribute to the overall cellular homeostasis and longevity.⁽⁸⁾

Decapeptide-12 is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.

References:

1. Jiang, L., Hino, P. D., Bhatia, A., Stephens, T. J., & Jimenez, F. (2018). Efficacy of Trifecting® Night Cream, a Novel Triple acting Skin Brightening Product: A Double-blind, Placebo-controlled Clinical Study. The Journal of clinical and aesthetic dermatology, 11(12), 21–25.
2. Ramírez, S. P., Carvajal, A. C., Salazar, J. C., Arroyave, G., Flórez, A. M., & Echeverry, H. F. (2013). Open-label evaluation of a novel skin brightening system containing 0.01% decapeptide-12 in combination with 20% buffered glycolic acid for the treatment of mild to moderate facial melasma. Journal of drugs in dermatology : JDD, 12(6), e106–e110.
3. Hantash, B. M., & Jimenez, F. (2012). Treatment of mild to moderate facial melasma with the Lumixyl brightening system. Journal of drugs in dermatology : JDD, 11(5), 660–662.
4. Hantash, B. M., & Jimenez, F. (2009). A split-face, double-blind, randomized and placebo-controlled pilot evaluation of a novel oligopeptide for the treatment of recalcitrant melasma. Journal of drugs in dermatology : JDD, 8(8), 732–735.
5. Bhatia, A., Hsu, J. T.s, & Hantash, B. M. (2014). Combined delivery and dermalinfusion of decapeptide-12 accelerates resolution of post-inflammatory hyperpigmentation in skin of color. Journal of drugs in dermatology : JDD, 13(1), 84–85.
6. Chen, J., Bian, J., Hantash, B. M., Albakr, L., Hibbs, D. E., Xiang, X., Xie, P., Wu, C., & Kang, L. (2021). Enhanced skin retention and permeation of a novel peptide via structural modification, chemical enhancement, and microneedles. International journal of pharmaceutics, 606, 120868. https://doi.org/10.1016/j.ijpharm.2021.120868
7. Kassim, A. T., Hussain, M., & Goldberg, D. J. (2012). Open-label evaluation of the skin-brightening efficacy of a skin-brightening system using decapeptide-12. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 14(2), 117–121. https://doi.org/10.3109/14764172.2012.672745
8. Basil, M. H., & Anan, A. U. (2019). Tyrosinase inhibitors with potent anti-senescence activity in human neonatal keratinocyte progenitors. J Dermatol Surg Res Ther, 2019, 30-39.

Semax is a synthetic peptide developed based on the molecular structure of the adrenocorticotropic hormone, which is produced by the pituitary gland. It was originally used in Russia for the prevention and treatment of circulatory disorders such as stroke. It has the ability to enhance cognition, protect brain cells, and ward off depression.

How Semax Works?

Semax works by stimulating certain parts of the brain involved in the release of brain-derived neurotrophic factor (BDNF). BDNF are chemicals involved in neurogenesis (formation of new neurons in the brain) and survival of existing neurons.

Potential Benefits of Semax

• Lowers the risk of heart disease [1-5]
• Boosts immunity [6-7]
• Accelerates wound healing [8-9]
• Improves brain health and performance [10-19]
• Lowers the risk of stroke [20-25]
• Improves mood [26-30]

Chemical Structure of Semax

Formula:    C₃₇H₅₁N₉O₁₀S
Molecular Weight:    813.93 g/mol

CAS.#: 80714-61-0

COG449 (OP449) Peptide – PP2A Activator & SET Inhibitor for Anti-Cancer Research

Product Name: COG449 (OP449)
 Synonyms: OP449, SET Inhibitor, PP2A Activator
 Sequence:

(Ac-RQIKIWFQNRRMKWKKCLRVRLASHLRKLRKRLL-NH2)-BMOE-(Ac-RQIKIWFQNRRMKWKKCLRVRLASHLRKLRKRLL-NH2)

 Molecular Formula: C₄₀₄H₆₉₄N₁₄₂O₇₆S₄
 Molecular Weight: 9223 g/mol
 CAS Number: Not Available
 Purity: >98%
 Appearance: White to off-white powder
 Application: For research use only
 Storage: −20°C (long term), sealed and protected from light and moisture
 Shipping: Ambient (domestic); varies for international orders

What is COG449 (OP449)?

COG449, also referred to as OP449, is a synthetic cell-penetrating peptide originally developed by Cognosci, Inc. and later advanced by Oncotide Pharmaceuticals. This research-grade peptide is a SET inhibitor that works by disrupting intracellular interactions critical for tumor survival and progression.

Mechanism of Action

COG449 targets and inhibits the SET oncoprotein, which is known to suppress the activity of protein phosphatase 2A (PP2A a well-established tumor suppressor. By blocking SET, COG449 peptide activates PP2A, potentially restoring its function in downregulating cancer-promoting pathways.

This peptide is being explored for its effects in anti-cancer research, especially in hematologic malignancies and drug-resistant solid tumors.

COG449 OP449 Peptide Benefits

●     SET Inhibition: Restores tumor suppressor activity of PP2A

●     PP2A Activation: Reactivates cellular control mechanisms over oncogenic signaling

●     Enhances Drug Sensitivity: Potentially improves efficacy of tyrosine kinase inhibitors

●     Preclinical Tumor Suppression: Shown to inhibit tumor cell proliferation in multiple cancer models

COG449 PP2A Activator Uses in Cancer Research

●     Leukemia Studies: Shows promise in suppressing cell viability in AML and CML models

●     Lymphoma Research: Investigated for effects in Burkitt’s lymphoma

●     Oral Squamous Cell Carcinoma Models: Demonstrates ability to interfere with tumor progression

●     Drug Resistance Investigations: Explored in combination therapies targeting tyrosine kinase resistance

Chemical Specifications

Buy COG449 PP2A Activator Online

Looking to buy COG449 OP449 peptide online for your laboratory or institution? We supply high-purity COG449 peptide designed for advanced cancer and cell signaling research. Bulk quantities and custom packaging available for academic, biotech, or pharmaceutical research.

Important Note

COG449 is not intended for human or veterinary use. It is strictly for laboratory research purposes. The safety and efficacy in humans have not been established, and it has not received regulatory approval as a therapeutic agent.

Introduction

Eyelitide-PlexÔ is a high-end composite raw material for the eye area containing 7 highly active peptide ingredients, which can comprehensively solve eye problems (eye wrinkles, eye bags and dark circles). Two high-content instant wrinkle-removing peptides can reduce the depth of wrinkles in the eye skin; three peptides derived from skin matrix can significantly improve skin texture and increase skin elasticity within 1 to 3 skin growth cycles; two ACE enzyme inhibitor peptides fight eye face edema and solve eye bags and dark circles in 15 days.

Mechanism of Action

·      Anti-aging and anti-wrinkle

High content of instant anti-wrinkle active peptide ingredients: 1) Tripeptide reduces wrinkles by inhibiting muscle contraction. Blocking the binding of acetylcholine to receptors eventually leads to receptor closure. In the closed state, sodium ions cannot be released, so the muscles relax; 2) Hexapeptide participates in the competition for SNAP-25 at the site of the melt-vesicle complex, thereby affecting the formation of the complex. The melt-vesicle complex is slightly unstable, and the vesicle cannot effectively release neurotransmitters, which leads to weakened muscle contraction and prevents the formation of wrinkles. Hexapeptide-3 can reduce the depth of wrinkles caused by facial expression muscle contraction, especially in the forehead and around the eyes.

Active peptide ingredients to improve skin quality: 1) Palmitoyl-pentapeptide micro-collagen chemically synthesized natural collagen micro-fragments, specifically acting on dermal cells, stimulating collagen synthesis, and maintaining the elastic surface of the skin; 2) Palmitoyl-tripeptide promotes collagen and polysaccharide synthesis; 3) Pal-tetrapeptide reduces the level of IL6 in aging, thereby achieving the goal of re-maintaining the balance of cytokines in the skin to achieve skin care.

·      Eye Bag Removal

1) Acetyl tetrapeptide inhibits ACE activity and improves blood circulation through antihypertensive effects; inhibits glycosylation; inhibits vascular permeability and prevents water from leaking from blood vessels; fights edema and relieves eye bags;

2) Dipeptide inhibits ACE enzyme, enhances lymphatic circulation and fights edema.

Efficacy and application:

Eye care products for removing eye bags and eye wrinkles, repairing eye contour, etc.

Product Specifications

As a professional beauty peptide supplier, after years of research and summary, Qualitide^Ò has a complete set of beauty peptide production processes and management systems. We produce peptides strictly in accordance with standards, and each batch of products undergoes strict quality inspections to ensure the high quality, high stability and high activity of the products. The raw material Qualitide provides to customers is compound eye peptide solution.

Eyelitide-Plex^TM

INCI Ingredients: Glycerin, Butylene, Glycol, Water, Carbomer, Tween- 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-5, Tripeptide-1, Acetyl Hexapeptide-8, Dipeptide-2, Acetyl Tetrapeptide-5

Appearance: Opalescent gel

Color: Off-white

Water content: 20~30%

pH: 4.0~6.0

Active ingredient content:

Palmitoyl Pentapeptide-4 (Matrixyl^TM, Pal-KTTKS)   100ppm  

Palmitoyl Tripeptide-1 (Pal-GHK)                                 100ppm

Palmitoyl Tetrapeptide-7 (Rigin^TM, Pal-GQPR)          50ppm

Tripeptide-1                                                         2000ppm

Acetyl Hexapeptide-8 (Argireline)                                500ppm

Dipeptide-2                                                                      1000ppm

Acetyl Tetrapeptide-5                                         1000ppm

Safety tests

In vitro and in vivo tests show that the Eyelitide-Plex^TM  did not show any cytotoxicity, skin irritation, allergy and eye irritation.

Usage and dosage:

Eyelitide-Plex^TM can be added in the final stage of cosmetic production, and the preparation temperature should be below 40°C. Based on the concentration of the Eyelid complex solution, 2~5% is recommended as the final product content to achieve significant anti-wrinkle and anti-eye bag activity. In order to avoid secondary microbial contamination, it should be used immediately after opening the cap.

Storage and Shelf Life

The compound eye peptide solution must be stored in a cool, dark and clean place to ensure a shelf life of at least 12 months. For long-term storage, it is recommended to store at 4°C, and the shelf life can be extended to at least 18 months.

Myristoyl Hexapeptide-23 (SymPeptide® 380) | Antibacterial & Collagen-Boosting Peptide for Acne-Prone Skin

Product Overview:

What Is Myristoyl Hexapeptide-23?

Myristoyl Hexapeptide-23 is a synthetic lipopeptide developed to target acne-causing bacteria, support collagen synthesis, and enhance skin firmness. Known for its dual-action effects, this peptide is used in formulations focused on treating acne, calming inflammation, and restoring youthful skin structure.

Whether you're formulating an anti-acne serum or a skin-conditioning cream, this multi-functional peptide is ideal for oily, irritated, or aging skin.

Chemical Info:

Synonym: SymPeptide® 380
INCI Name: Myristoyl-Ala-Lys-Lys-Leu-Lys-Leu-NH₂

Formula: C₄₉H₉₆N₁₀O₉

Mol. Weight: 969.3 g/mol
CAS #: Not assigned
 Form: White Powder
 Purity: ≥ 99%
 Solubility: Soluble in water, propylene glycol, ethanol

Key Benefits of Myristoyl Hexapeptide-23

●     Anti-Acne & Antibacterial: Eliminates Cutibacterium acnes (formerly P. acnes), reducing inflammation and breakouts.

●      Sebum Control: Helps regulate oil production to prevent pore blockage.

●     Soothes & Conditions Skin: Calms irritation and supports overall skin barrier health.

●     Myristoyl Hexapeptide-23 Collagen Boosting: Stimulates dermal matrix components, improving elasticity and texture.

●      Myristoyl Hexapeptide-23 Skin Firming Benefits: Enhances firmness by supporting collagen and structural proteins.

●     Prevents Skin Infections: Ideal for reducing the risk of folliculitis and other acne-related complications.

Functions

●     Antibacterial: Targets acne-causing bacteria for clearer skin.

●     Anti-Inflammatory: Calms redness, irritation, and swelling.

●     Skin-Firming & Collagen-Enhancing: Boosts elasticity and combats early signs of aging.

●     Preventative Care: Guards against acne recurrence and bacterial infections.

Myristoyl Hexapeptide-23 vs Matrixyl 3000

While Matrixyl 3000 focuses on wrinkle reduction through peptide signaling, Myristoyl Hexapeptide-23 offers a dual-action approach: anti-bacterial support for acne-prone skin plus collagen stimulation. It’s especially beneficial for younger users dealing with acne who also want anti-aging benefits.

Applications

Formulate Myristoyl Hexapeptide-23 into:

●      Acne creams and spot treatments

●      Anti-bacterial serums and face washes

●      Pore-clearing toners for oily skin

●      Skin-firming solutions for acne-prone or sensitive skin

●      Post-treatment skin recovery products

Recommended Usage Rate: 0.5%–2%
 Storage: Store in a cool, dry place. Refrigerate after opening.

Buy Myristoyl Hexapeptide-23 Online

Looking to buy Myristoyl Hexapeptide-23 online? We offer high-purity, research-grade peptide powder suitable for cosmetic formulations and skincare R&D. Bulk quantities and custom packaging available.

Note: For external use in cosmetic or research applications only. Not for injection or ingestion.

Semaxx, developed in Russia during the 1980s, is a synthetic peptide derived from a segment of the adrenocorticotropic hormone (ACTH). Initially formulated to aid stroke recovery and cognitive impairments, it has since become popular as a cognitive enhancer due to its neuroprotective and nootropic properties. Semaxx Nasal Spray increases brain-derived neurotrophic factor (BDNF) levels, which supports neuron growth and cognitive function, often resulting in enhanced memory, focus, and mental clarity. Selank offers anxiolytic effects that help reduce stress and promote calmness without the sedative side effects common to traditional anti-anxiety treatments.

Benefits of Semaxx & Selank Nasal Spray

• Cognitive Enhancement: Semaxx boosts brain-derived neurotrophic factor (BDNF) levels, which supports neuron growth and cognitive function. Users often report improved memory, focus, and mental clarity.
• Stress and Anxiety Reduction: Selank is known for its anxiolytic properties, helping to reduce stress and promote a sense of calm without the sedative effects of traditional anti-anxiety medications.
• Mood Improvement: The combination of Semaxx and Selank may enhance mood, helping to alleviate symptoms of depression and improve overall emotional well-being.
• Neuroprotection: Semaxx has been shown to protect neurons from damage, making it a valuable tool for long-term brain health.

About this item:

• Copper Tripeptide-1: This lightweight serum offers targeted support for fine lines and wrinkles for a more youthful appearance.
• Revitalize Your Skin: Qualtide's Copper Peptide Serum with Argireline, another well known anti-wrinkle peptide, combines the rejuvenating power of copper peptides to deliver visible results.
• Advanced Skin Renewal: Expertly formulated for both men and women, Copper Tripeptide-1 (GHK-Cu) is a powerful anti-aging ingredient known for promoting collagen and elastin production, which helps to improve skin firmness and reduce the appearance of fine lines and wrinkles..
• Scar Healing Aid: Copper peptides are found to support the skin's natural self-repair mechanisms. This not only aids in diminishing the appearance of scars but also promotes a more even, harmonized skin tone.
• Intense Hydration: Hyaluronic acid, an ingredient known as the most potent moisturing factor in the body. HA can hold up to 1000 times its weight in water, making it a powerful humectant.  Qualitide's hyaluronic acid formula contains both high molecule weight (HMW-HA) and low molecule weight of HA (LMW-HA). The HMW-HA will create a moisturing layer on the surface of skin while LMW-HA can be absorpted and retains the water underneath the skin. Together, the formula provides long-lasting moisture contributing to tissue elasticity, suppleness and plumpness.
• Premium Quality & Transparency: Crafted with top-tier ingredients for optimal skin benefits, produced in a GMP-certified facility in the USA, and backed by third-party lab tests to ensure clarity on active ingredients.

Active Ingredients:

• Copper Tripeptide-1 (GHK-Cu)
• Acetyl Hexapeptide-8 (Argireline)
• Hyaluronic Acid (High Molecular Weight, 1000-1300 KDa)
• Hyaluronic Acid (Low Molecular Weight, 200-400 KDa)
• Hyaluronic Acid (High Molecular Weight, 1000-1300 KDa)
• Vegetable Glycerin